Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy |
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Document Language |
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English |
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Abstract |
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Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN)
therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen
planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed
between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid
hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls.
The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the
levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that
thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody
(TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid
hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these
enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the
recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct
toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly
demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity
against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders. |
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ISSN |
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2814-9047 |
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Journal Name |
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Bioinformation |
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Volume |
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12 |
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Issue Number |
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3 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Thursday, July 20, 2017 |
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Researchers
| Mahwish Arooj | Arooj, Mahwish | Researcher | Doctorate | |
| Arif Malik | Malik, Arif | Researcher | Doctorate | |
| Abdul Basit | Basit, Abdul | Researcher | Doctorate | |
| Mahmood Husain Qazi | Qazi, Mahmood Husain | Researcher | Doctorate | |
| Muhammad Asif | Asif, Muhammad | Researcher | Doctorate | |
| Mohammad Sarwar Jamal | Jamal, Mohammad Sarwar | Researcher | Doctorate | |
| Maged Mostafa Mahmoud | Mahmoud, Maged Mostafa | Researcher | Doctorate | |
| Hani Choudhry | Choudhry, Hani | Researcher | Doctorate | |
| Peter Natesan Pushparaj | Pushparaj, Peter Natesan | Researcher | Doctorate | |
| Mahmood Rasool | Rasool, Mahmood | Researcher | Doctorate | mahmoodrasool@yahoo.com |
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