تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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استخدام فيتامين د لعلاج وهن العضلات الشديد Severe proximal myopathy with remarkable recovery after vitamin D treatment. |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Background: Osteomalacia is an uncommon cause of muscle weakness. Our objectives were to describe features of myopathy associated with Vitamin D deficiency and examine the contributing factors leading to osteomalacic myopathy in our region. Methods: A series of consecutive patients with proximal myopathy associated with vitamin D deficiency were identified retrospectively over a 6 year period ending December, 2006. Patients were followed in 3 major centers in western Saudi Arabia. Clinical, biochemical, radiological, and electrophysiological findings were collected before and after Vitamin D treatment by chart review. Results: Forty seven female patients aged 13-46 years (mean 23.5, SD 4.5) were included. All were veiled and covered heavily when outside the house for social and cultural reasons. Only 8 (17%) had adequate varied diet with daily milk ingestion. All patients presented with progressive proximal muscle weakness lasting 6-24 months (mean 14) prior to our evaluation. The weakness was severe in 6 (13%) patients leading to wheel chair bound states. Associated musculoskeletal pain involving the back, hips, or lower limbs was common (66%). Osteomalcia was the referral diagnosis in only 11 patients and the remaining 36 (77%) patients were misdiagnosed. All patients had metabolic and radiological profiles suggestive of osteomalacia. Remarkable recovery was documented in all patients following oral cholecalciferol and calcium supplementation. Conclusions: Vitamin D deficiency is an important treatable cause of osteomalacic myopathy in Saudi Arabia. The diagnosis is frequently delayed or missed. Screening for Vitamin D deficiency in patients with acquired myopathy is needed to identify this treatable disorder. |
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ردمد |
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0306-4522 |
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اسم الدورية |
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Canadian Journal of Neurological Sciences |
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المجلد |
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3 |
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العدد |
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36 |
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سنة النشر |
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2009 هـ
2009 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Wednesday, March 10, 2010 |
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الباحثون
| محمد جان | jan, Mohammed | باحث | دكتوراه | |
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الرجوع إلى صفحة الأبحاث
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